Reference of 288-88-0, New Advances in Chemical Research in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 288-88-0, name is 1H-1,2,4-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
Weigh p-iodoaniline (300.0mg, 1.37mmol), 1H-1,2,4- Triazole (113.4mg, 1.64mmol), CuI (26.0mg, 0.14mmol), cesium carbonate (624.7mg, 1.92mmol), 8-hydroxyquinoline (39.7mg, 0.27mmol) was placed in a 50mL single-necked flask, and mixed The solvent DMF: H2O (10: 1) was reacted at 110 C for 24 hours. After confirming the completion of the reaction by TLC, water was added, EA was extracted, and anhydrous sodium sulfate was dried. After concentration, it was purified through a silica gel column using a mobile phase with petroleum ether and ethyl acetate (V / V = 1/1) to obtain 4- (1H- 1,2,4-triazol-1-yl) aniline 3r was used as the starting material for the next reaction.
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Reference:
Patent; Wuhan University; Wu Shuwen; Zhou Haibing; Xu Zhichao; (24 pag.)CN110483425; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics