Research speed reading in 2021. We’ll be discussing some of the latest developments in chemical about CAS: 4314-22-1, name is 2-(1H-1,2,3-Triazol-1-yl)acetic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 4314-22-1
Step C N-Methoxy-N-methyl-2-(1-(1, 2, 3-triazolyl)) acetamide Oxalyl chloride (0.95 mL, 11 mmol) was added dropwise to a suspension of 2- (1-1, 2,3-triazolyl)) acetic acid (Step B, 1.27 g, 10 mmol) in 10 mL CH2C12 containing 0.05 mL DMF. Vigorous effervescence was observed. This mixture was stirred at room temperature for 4 h and cooled to-78C. A solution of N. O- dimethylhydroxylamine hydrochloride (1.2 g, 13 mmol) and diisopropylethyl amine (6.0 mL, 35 mmol) in 10 mL CH2C12 was added slowly over 3 min. The mixture was then allowed to warm to room temperature and stirred overnight. The reaction mixture was then diluted with ether until no additional precipitate appeared. The solid was filtered and washed with ether. The filtrate was concentrated and the residue was purified on silica gel using EtOAc as solvent to provide the title compound as amorphous solid.
In conclusion, we affirm that quantitative kinetic descriptions of catalytic behavior continue to serve as an indispensable tool to navigate research efforts intended to model. Read on for other articles about 4314-22-1.
Reference:
Patent; MERCK & CO., INC.; WO2005/44785; (2005); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics