Research speed reading in 2021. Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 584-13-4, name is 4H-1,2,4-Triazol-4-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 584-13-4
12.78 grams of sodium hypochlorite solution (36mM available chlorine) was dissolved inthe solution formed by mixing 5 mL glacial acetic acid with 30 mL of deionized water and the solution was cooled to 7 C. To this was added 1.5 g (18 mM) 4-amino-1,2,4-triazole dissolved in 15 mL deionized water. The solution was stirred at 7 C for 4 h followed by standing the final solution two days at room temperature. Yellow and oblong crystal of atrz (Supplemental data, figure S1) was obtained in 75% yield (scheme 1). This is very good for the synthesis of atrz, because the separation of the product, we know, always is the most difficult step during the whole synthetic experiment. In addition, sodium chloride, totally environment friendly, will only be left after atrz is separated from the final solution. Caution: The light, which makes sodium hypochlorite turn into sodium chloride and oxygen, must be obstructed during the whole reaction. Temperature is also very important to the yield of atrz because sodium hypochlorite is very unstable at high temperature (>25 C).Anal. Calcd for C4N8H4: C, 29.24; N, 68.32; H, 2.44. Found: C, 28.93; N, 68.36; H, 2.49. IR(cm-1) = 3111(s), 1489(s), 1368(s), 1315(m), 1176(s).
The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 584-13-4
Reference:
Article; Li; Wu; Qiu; Zhang; Yang; Journal of Coordination Chemistry; vol. 67; 11; (2014); p. 2016 – 2027;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics