Research speed reading in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 16681-65-5, name is 1-Methyl-1H-1,2,3-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. 16681-65-5
Compound 6. To a solution of compound 4 (5 g, 60 mmol, 1 eq.) in THF (120 mL) was added LDA (2M in THF, 45 mL, 1.5 eq.) dropwise at -78 C under N2. After the mixture was stirred at -78 C for 1 h, compound 5 (6.33 g, 90.3 mmol, 6.7 mL, 1.5eq.) was added dropwise at -78 C. The mixture was stirred at -78 C for additional 2 h under N2. The reaction mixture was then poured into ice sat. NH4Cl (100 mL) and extracted with DCM (150 mL x 5). The combined organics were washed with brine (200 mL), dried over Na2SO4, filtered, concentrated, and purified by column chromatography (SiO2, petroleum ether/ethyl acetate (1:1 to 0:1)) to afford compound 6 as a yellow solid. 1H-NMR (CDCl3, 400 MHz) delta 7.61 (s, 1H), 4.16-4.12 (m, 1H), 4.11 (s, 3H), 2.82 (d, J = 5.1 Hz, 1H), 1.37 (tq, J = 4.9, 8.2 Hz, 1H), 0.78-0.66 (m, 2H), 0.57-0.48 (m, 1H), 0.42-0.30 (m, 1H).
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 1-Methyl-1H-1,2,3-triazole, in my other articles.
Reference:
Patent; YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD.; SNIR-ALKALAY, Irit; VACCA, Joseph; BEN-NERIAH, Yinon; (238 pag.)WO2019/155468; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics