Reference of 288-36-8, New Advances in Chemical Research in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 288-36-8, name is 1H-1,2,3-Triazole, molecular formula is C2H3N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
1- (3-CHLORO-PROPOXY)-4-NITRO-BENZENE (7 g, 32.5 mmol) is dissolved in 2-methyl- 2-butanol (35 ml) followed by the addition of 1H-1, 2,3-triazole (3.43 g, 48.7 mmol), potassium iodide (0.54 g, 3.25 mmol) and sodium hydroxide (1.95 g, 48.7 mmol). The mixture is stirred for 20 h at 120 C, evaporated to dryness and suspended in toluene. Washing with water, drying over sodium sulfate and concentration in vacuo yields a crude product, which is washed with ether yielding L- [3- (4-NITRO-PHENOXY)-PROPYL]-LH- [L, 2,3] triazole as a colorless solid. Yield 6 g (75 %) MS: M = 249.3 (API+) H-NMR (400 MHz, CDC13) : 2.48 (m, 2H), 4.07 (t, J = 5.77 Hz, 2H), 4.64 (t, J = 6.7 Hz, 2H), 6.93 (d, J = 9.3 Hz, 2H), 7.56 (s, 1H), 7.72 (s, 1H), 8.20 (d, J = 9.2 Hz, 2H).
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/96796; (2004); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics