I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Chemical modifications of ergostane-type triterpenoids from Antrodia camphorata and their cytotoxic activities published in 2021.0. Recommanded Product: 1H-1,2,4-Triazol-5-amine, Reprint Addresses Liang, L; Ye, M (corresponding author), Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, 38 Xueyuan Rd, Beijing 100191, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
In order to discover potential antitumor agents from natural products, chemical modifications of ergostane-type triterpenoids from Antrodia camphorata yielded ten new compounds. They include nine C-26 amide derivatives of antcin G (1) and a methyl antcin B (4) derivative with hydroxyamino groups at C-3 and C-7. Chemical structures of the new compounds were elucidated by NMR and MS analyses. Furthermore, cytotoxicities of the triterpenoid derivatives were evaluated using four human cancer cell lines (HL60, U251, SW480, and MCF-7). As a result, 1a, 1g, and 4a exhibited potent cytotoxic activities against HL60, U251, and SW480 with IC50 values of 0.7 +/- 0.9, 2.9 +/- 1.3, and 2.2 +/- 0.6 mu M, respectively. Molecular docking indicates that 1a, 1g, and 4a have strong binding affinity with DNA topoisomerase II alpha (-9.3, -7.9, and -7.4 kcal/mol, respectively), and that they could be potent topoisomerase II alpha inhibitors.
Recommanded Product: 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Li, B; Kuang, Y; Yi, Y; Qiao, X; Liang, L; Ye, M or concate me.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics