I found the field of Chemistry very interesting. Saw the article The Aminotriazole Antagonist Cmpd-1 Stabilises a Distinct Inactive State of the Adenosine 2A Receptor published in 2019.0. COA of Formula: C2H4N4, Reprint Addresses Crump, MP (corresponding author), Univ Bristol, Sch Chem, Bristol BS8 1TS, Avon, England.; Joedicke, L (corresponding author), UCB Celltech, 216 Bath Rd, Slough SL1 3WE, Berks, England.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
The widely expressed G-protein coupled receptors (GPCRs) are versatile signal transducer proteins that are attractive drug targets but structurally challenging to study. GPCRs undergo a number of conformational rearrangements when transitioning from the inactive to the active state but have so far been believed to adopt a fairly conserved inactive conformation. Using (FNMR)-F-19 spectroscopy and advanced molecular dynamics simulations we describe a novel inactive state of the adenosine 2A receptor which is stabilised by the aminotriazole antagonist Cmpd-1. We demonstrate that the ligand stabilises a unique conformation of helix V and present data on the putative binding mode of the compound involving contacts to the transmembrane bundle as well as the extracellular loop 2.
COA of Formula: C2H4N4. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Landin, EJB; Lovera, S; de Fabritiis, G; Kelm, S; Mercier, J; McMillan, D; Sessions, RB; Taylor, RJ; Sands, ZA; Joedicke, L; Crump, MP or concate me.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics