An article Antimicrobial Effect of a Novel Chitosan Derivative and Its Synergistic Effect with Antibiotics WOS:000612551400104 published article about CHEMICAL-MODIFICATIONS; EFFLUX PUMPS; NANOPARTICLES; RESISTANCE; MODE; GENERATION; BACTERIA; DELIVERY; MICRO in [Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Chan-Park, Mary B.] Nanyang Technol Univ NTU, Sch Chem & Biomed Engn, Singapore 637459, Singapore; [Si, Zhangyong; Hou, Zheng; Vikhe, Yogesh Shankar; Thappeta, Kishore Reddy Venkata; Chan-Park, Mary B.] Nanyang Technol Univ, Ctr Antimicrobial Bioengn, Singapore 637459, Singapore; [Thappeta, Kishore Reddy Venkata] Nanyang Technol Univ, Singapore Ctr Environm & Life Sci SCELSE, Singapore 637551, Singapore; [Marimuthu, Kalisvar; Ng, Oon Tek] Tan Tock Seng Hosp, Dept Infect Dis, Singapore 308442, Singapore; [Marimuthu, Kalisvar; Ng, Oon Tek] Natl Ctr Infect Dis, Singapore 637459, Singapore; [De, Partha Pratim] Tan Tock Seng Hosp, Dept Lab Med, Singapore 308433, Singapore; [Ng, Oon Tek; Pethe, Kevin] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 636921, Singapore; [Li, Peng] Northwestern Polytech Univ, Inst Flexible Elect, Xian 710072, Peoples R China; [Zhu, Yabin] Ningbo Univ, Med Sch, Ningbo 315211, Zhejiang, Peoples R China; [Pethe, Kevin] Nanyang Technol Univ, Sch Biol Sci, Singapore 636921, Singapore; [Chan-Park, Mary B.] Nanyang Technol Univ, Lee Kong Chian Sch Med, Singapore 637459, Singapore; [Chan-Park, Mary B.] Nanyang Technol Univ, Sch Phys & Math Sci, Singapore 637459, Singapore in 2021.0, Cited 49.0. Quality Control of 1H-1,2,4-Triazol-5-amine. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5
Cationic polymers are promising antibacterial agents because bacteria have a low propensity to develop resistance against them, but they usually have low biocompatibility because of their hydrophobic moieties. Herein, we report a new biodegradable and biocompatible chitosan-derived cationic antibacterial polymer, 2,6-diamino chitosan (2,6-DAC). 2,6-DAC shows excellent broad-spectrum antimicrobial activity with minimum inhibitory concentrations (MICs) of 8-32 mu g/mL against clinically relevant and multidrug-resistant (MDR) bacteria including Listeria monocytogenes, Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Acinetobacter baumannii. Furthermore, 2,6-DAC shows an excellent synergistic effect with various clinically relevant antibiotics proved by decreasing the MICs of the ntibiotics against MDR A. baumannii and methicillin-resistant Staphylococcus aureus to <1 mu g/mL. In vivo biocompatibility of 2,6-DAC is proved by a dosage of 100 mg/kg compound via oral administration and 25 mg/kg compound via intraperitoneal injection to mice; 2,6-DAC does not cause any weight loss and any significant change in liver and kidney biomarkers or the important blood electrolytes. The combinations of 2,6-DAC together with novobiocin and rifampicin show >2.4 log(10) reduction of A. baumannii in murine intraperitoneal and lung infection models. The novel chitosan derivative, 2,6-DAC, can be utilized as a biocompatible broad-spectrum cationic antimicrobial agent alone or in synergistic combination with various antibiotics.
Quality Control of 1H-1,2,4-Triazol-5-amine. Welcome to talk about 61-82-5, If you have any questions, you can contact Si, ZY; Hou, Z; Vikhe, YS; Thappeta, KRV; Marimuthu, K; De, PP; Ng, OT; Li, P; Zhu, YB; Pethe, K; Chan-Park, MB or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
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