Quality Control of 6-Methylnicotinic acid. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 6-Methylnicotinic acid, is researched, Molecular C7H7NO2, CAS is 3222-47-7, about Enantioselective Synthesis of Dihydropyridines Containing Quaternary Stereocenters Through Dearomatization of Pyridinium Salts. Author is Robinson, Donovan J.; Spurlin, Sean P.; Gorden, John D.; Karimov, Rashad R..
Enantioselective synthesis of non-aromatic heterocycles containing a quaternary stereogenic center is a challenging synthetic problem. A strategy towards this problem involving dearomatization of N-alkylpyridinium salts using boronic acid nucleophiles have been described. This dearomatization reaction is catalyzed by Rhodium(I)/BINAP catalyst and delivers dihydropyridines that contain a fully substituted stereogenic center alpha to the ring nitrogen atom in high yield and enantioselectivity. The reaction is compatible with a wide range of functional groups such as halide, ester, amide, olefin and free alc. Derivatization of dehydropyridine products allows synthesis of the functionalized tetrahydropyridines and piperidines.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics