Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, ACS Medicinal Chemistry Letters called Escaping from Flatland: Antimalarial Activity of sp3-Rich Bridged Pyrrolidine Derivatives, Author is Cox, Brian; Duffy, James; Zdorichenko, Victor; Bellanger, Corentin; Hurcum, Jessica; Laleu, Benoit; Booker-Milburn, Kevin I.; Elliott, Luke D.; Robertson-Ralph, Michael; Swain, Christopher J.; Bishop, Stephen J.; Hallyburton, Irene; Anderson, Mark, which mentions a compound: 3222-47-7, SMILESS is O=C(O)C1=CN=C(C)C=C1, Molecular C7H7NO2, Product Details of 3222-47-7.
Synthetic photochem. to generate novel sp3-rich scaffolds and report the design, synthesis, and biol. testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane scaffold was utilized . Preliminary antimalarial screening of the library provided promising compounds with activity in the 1-5μM range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality.
If you want to learn more about this compound(6-Methylnicotinic acid)Product Details of 3222-47-7, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(3222-47-7).
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics