Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Huaxi Yaoxue Zazhi called Synthesis of fluconazole, Author is Wang, Jianxiang, which mentions a compound: 86404-63-9, SMILESS is FC1=CC=C(C(CN2N=CN=C2)=O)C(F)=C1, Molecular C10H7F2N3O, Name: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone.
The improved synthetic technol. of fluconazole was presented. Fluconazole was produced by 4-step reactions with m-difluorobenzenes as starting material and PEG as phase-transfer catalyst, including acylating with chloroacetyl chloride, substitution reaction with 1,2,4-triazole, the reaction with Me3SOI, and ring opening with 1,2,4-triazole. The product could remove impurity of identical structure after recrystallization, with a yield above 50%. The purity of product was above 98.5%, the quality was stable, and the process is reliable.
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Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics