In 2016,Amin, Kamelia M.; Abd El-Meguid, Eman A.; El-Assaly, Samy A.; El-Hamouly, Wageeh S. published 《Synthesis, antibreast cancer activity and docking study of some novel 4-(benzo [d] thiazol-2-yl) phenyl moiety as CDK2 inhibitors》.International Journal of Pharmacy and Technology published the findings.Computed Properties of C12H22F6N6OP2 The information in the text is summarized as follows:
Some novel sulfonamides, Schiff’s bases and pyrrole derivatives attached to 4-benzo[d]thiazol-2-yl were prepared Some of the newly synthesized compounds have been evaluated for their potential cytotoxicity against breast cancer cell line (MCF-7) in comparison with doxorubicin; the urea derivative 6a exhibited the highest activity. Mol. docking into CDK2 has been done for lead optimization of the compounds in study as potential CDK2 inhibitors; compound 8b showed the lowest binding score. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6Computed Properties of C12H22F6N6OP2)
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.Computed Properties of C12H22F6N6OP2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics