Jiu, Alexander Y.; Slocumb, Hannah S.; Yeung, Charles S.; Yang, Xiao-Hui; Dong, Vy M. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Enantioselective Addition of Pyrazoles to Dienes》.Application of 288-36-8 The article contains the following contents:
We report the first enantioselective addition of pyrazoles to 1,3-dienes [e.g., 1H-pyrazole + (E)-1-phenyl-1,3-butadiene → I (91%, 96:4 er)]. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd0-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8) was used in this study.
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics