The author of 《Chemoenzymatic Synthesis of O-Mannose Glycans Containing Sulfated or Nonsulfated HNK-1 Epitope》 were Gao, Tian; Yan, Jingyu; Liu, Chang-Cheng; Palma, Angelina S.; Guo, Zhimou; Xiao, Min; Chen, Xi; Liang, Xinmiao; Chai, Wengang; Cao, Hongzhi. And the article was published in Journal of the American Chemical Society in 2019. Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The author mentioned the following in the article:
The human natural killer-1 (HNK-1) epitope is a unique sulfated trisaccharide sequence presented on O- and N-glycans of various glycoproteins and on glycolipids. Herein, we describe a highly efficient chemoenzymic approach for the first collective synthesis of HNK-1-bearing O-mannose glycans with different branching patterns, and their non-sulfated counterparts. The successful strategy relies on both chem. glycosylation of a trisaccharide lactone donor for the introduction of sulfated HNK-1 branch, and on substrate bacterial glycosyltransferases that can tolerate sulfated substrates for enzymic diversification. Glycan microarray anal. with the resulting complex synthetic glycans demonstrated their recognition by two HNK-1-specific antibodies including anti-HNK-1/N-CAM (CD57) and Cat-315, which provided further evidence for the recognition epitopes of these antibodies and the essential roles of the sulfate group for HNK-1 glycan-antibody recognition. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics