The author of 《Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids》 were Heise, Torben; Pijnenborg, Johan F. A.; Buell, Christian; van Hilten, Niek; Kers-Rebel, Esther D.; Balneger, Natasja; Elferink, Hidde; Adema, Gosse J.; Boltje, Thomas J.. And the article was published in Journal of Medicinal Chemistry in 2019. Related Products of 510758-28-8 The author mentioned the following in the article:
Sialic acid sugars on mammalian cells regulate numerous biol. processes, while aberrant expression of sialic acid is associated with diseases such as cancer and pathogenic infection. Inhibition of the sialic acid biosynthesis may therefore hold considerable therapeutic potential. To effectively decrease the sialic acid expression, we synthesized C-5-modified 3-fluoro sialic acid sialyltransferase inhibitors. We found that C-5 carbamates significantly enhanced and prolonged the inhibitory activity in multiple mouse and human cell lines. As an underlying mechanism, we have identified that carbamate-modified 3-fluoro sialic acid inhibitors are more efficiently metabolized to their active cytidine monophosphate analogs, reaching higher effective inhibitor concentrations inside cells. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8) was used in this study.
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics