The author of 《Identification of HSP90 as a direct target of artemisinin for its anti-inflammatory activity via quantitative chemical proteomics》 were Wu, Guolin; Cheng, Bao; Qian, Hui; Ma, Shengming; Chen, Qin. And the article was published in Organic & Biomolecular Chemistry in 2019. Formula: C30H30N10 The author mentioned the following in the article:
The anti-malarial drug artemisinin (ART) possesses potent antiinflammatory activity, yet its underlying mechanism of action has remained elusive. Here the authors employed quant. chem. proteomics to in situ profile the cellular targets of ART and identified heat shock protein 90 (HSP90) as a direct target. Further study revealed that ART suppressed the production of nitric oxide (NO) in macrophages via inhibiting the interaction between HSP90 and inducible NO synthase (iNOS).Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Formula: C30H30N10) was used in this study.
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Formula: C30H30N10
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics