In 2018,Organic & Biomolecular Chemistry included an article by Li, Pan; Chen, Zhe; Huang, Yishun; Li, Jing; Xiao, Fan; Zhai, Shiyao; Wang, Zhiming; Zhang, Xuanjun; Tian, Leilei. Electric Literature of C30H30N10. The article was titled 《A pH responsive fluorescent probe based on dye modified i-motif nucleic acids》. The information in the text is summarized as follows:
A new DNA-based fluorescent probe, which is a hybrid mol. of an i-motif forming sequence (IFS) and mono-functionalized tetraphenylethene (TPE), has been synthesized and investigated. A distinct pH-responsive aggregation-induced emission (AIE) effect has been observed from this hybrid mol., i.e. the fluorescence of TPE will be turned on when the IFS part folds up under acidic conditions. According to the fact that a hybrid mol. with a relatively rigid structure shows a more obvious AIE effect, and whose nano-sized aggregates are formed at a high concentration, we assume that the solubility of the hybrid mol. in water will be reduced due to IFS folding, resulting in aggregation and the resultant AIE effect. Finally, due to its excellent pH responsiveness, this DNA-based probe employing an AIEgen has been applied in monitoring intracellular pH. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Electric Literature of C30H30N10)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Electric Literature of C30H30N10
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics