In 2022,Mokariya, Jaydeep A.; Kalola, Anirudhdha G.; Prasad, Pratibha; Patel, Manish P. published an article in Molecular Diversity. The title of the article was 《Simultaneous ultrasound- and microwave-assisted one-pot ‘click’ synthesis of 3-formyl-indole clubbed 1,2,3-triazole derivatives and their biological evaluation》.Safety of 1H-1,2,3-Triazole The author mentioned the following in the article:
An environment friendly, high yielding, promising one-pot protocol for the click reaction of N-propargyl-3-formylindoles, chloroacetic acid/ester and sodium azide, leading to the formation of 3-formyl-indole clubbed 1,4-disubstituted-1,2,3-triazole derivatives I [R = OH, OEt, Ph, etc.; R1 = H, Me] aided by CuI catalyst accomplished under acceleration of simultaneous ultrasound and microwave irradiation in a very short reaction time was described. Further, acid derivatives I [R = OH; R1 = H, Me] were subjected to acid-amine coupling reaction with secondary amines in the presence of HATU to afford triazoles II [R2 = 4-methylpiperidin-1-yl, 2-morpholino, 1,2,3-triazol-1-yl, etc.]. The perspective of this protocol was to get rid of the hectic preparation and handling of organic azide which are generated in situ. Consequently, this protocol blossomed the click process by making it environment benign, user-friendly, safe and clean technique. All the synthesized compounds were preliminarily screened for their in vitro antimicrobial activity against a panel of pathogenic strains. The majority of compounds possessed noticeably inhibitory action against E. Coli, S. Typhi, P. Aeruginosa, C. tetani, S. aureus and B. subtillis. Among all compounds, I [R1 = H, R2 = 4-methylpiperidin-1-yl; R1 = Me, R2 = 4-methylpiperazin-1-yl] exhibited excellent inhibitory action against E.Coli and P. Aeruginosa strain, resp., as compared to standard drug. One compound I [R = Me, R1 = OEt] showed remarkable potency against fungal strain. Mol. docking study was carried out to understand binding of compound with protein. In silico ADME prediction was carried out to check physicochem. properties of synthesized compound1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole) was used in this study.
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics