The author of 《Ramified derivatives of 5-(perylen-3-ylethynyl)uracil-1-acetic acid and their antiviral properties》 were Sapozhnikova, Ksenia A.; Slesarchuk, Nikita A.; Orlov, Alexey A.; Khvatov, Evgeny V.; Radchenko, Eugene V.; Chistov, Alexey A.; Ustinov, Alexey V.; Palyulin, Vladimir A.; Kozlovskaya, Liubov I.; Osolodkin, Dmitry I.; Korshun, Vladimir A.; Brylev, Vladimir A.. And the article was published in RSC Advances in 2019. Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The author mentioned the following in the article:
The propargylamide of N3-Pom-protected 5-(perylen-3-ylethynyl)uracil acetic acid, a universal precursor, was used in a CuAAC click reaction for the synthesis of several derivatives, including three ramified mols. with high activities against tick-borne encephalitis virus (TBEV). Pentaerythritol-based polyazides were used for the assembly of mols. containing 2…4 antiviral 5-(perylen-3-ylethynyl)uracil scaffolds, the first examples of polyvalent perylene antivirals. Cluster compounds showed enhanced absorbance, however, their fluorescence was reduced due to self-quenching. Due to the solubility issues, Pom group removal succeeded only for compounds with one peryleneethynyluracil unit. Four compounds, including one ramified cluster 9f, showed remarkable 13 nM EC50 values against TBEV in cell culture. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics