《Stapling proteins in the RELA complex inhibits TNFα-induced nuclear translocation of RELA》 was written by Kour, Smit; Rana, Sandeep; Kizhake, Smitha; Lagundzin, Dragana; Klinkebiel, David; Mallareddy, Jayapal Reddy; Huxford, Tom; Woods, Nicholas T.; Natarajan, Amarnath. Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineThis research focused ontumor necrosis factor alpha stapling protein RELA nuclear translocation. The article conveys some information:
Tumor necrosis factor (TNF) α-induced nuclear translocation of the NF-ΚB subunit RELA has been implicated in several pathol. conditions. Here we report the discovery of a spirocyclic dimer (SpiD7) that covalently modifies RELA to inhibit TNFα-induced nuclear translocation. This is a previously unexplored strategy to inhibit TNFα-induced NF-ΚB activation. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics