Category: triazolesIn 2019 ,《Three-Component Protein Modification Using Mercaptobenzaldehyde Derivatives》 appeared in Organic Letters. The author of the article were Dai, Yuanwei; Weng, Jiaping; George, Justin; Chen, Huan; Lin, Qishan; Wang, Jun; Royzen, Maksim; Zhang, Qiang. The article conveys some information:
A chemoselective primary amine modification strategy that enables the three-component, one-pot bioconjugation is described. The specifically designed, mercaptobenzaldehyde-based bifunctional linker achieves highly selective and robust amine labeling under biocompatible conditions. This linker demonstrates wide functional group tolerance and is simple to prepare, which allowed facile payload incorporation. Finally, the studies have shown that the introduction of linker does not impair the function of modified protein such as insulin. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Category: triazoles)
Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Category: triazoles
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics