HPLC of Formula: 56602-33-6In 2018 ,《An efficient PyAOP-based C4-amination method for direct access of oxidized 5-methyl-2′-deoxycytidine derivatives》 appeared in Tetrahedron. The author of the article were Zheng, Xiu-An; Huang, Hua-Shan; Kong, Rui; Chen, Wei-Jie; Gong, Shan-Shan; Sun, Qi. The article conveys some information:
In the past decade, synthetic oxidized 5-methyl-2′-deoxycytidine nucleosides and their derivatives have become essential tools for epigenetic research. The low efficacy of both conventional and newly reported BOP methods on C4-amination of these specific oxidized 5-MedU substrates urged us to systematically investigate how the nature of onium salt-based coupling reagents affects the C4-amination of pyrimidine nucleobases and lead us to the findings that different onium coupling reagents result in the formation of distinctive activation intermediates and PyAOP is much more potent than BOP in both activation and aminolysis steps. Direct amination without the need of ribose protection, ultrafast activation, tolerance to aqueous N-nucleophiles, and excellent yields for diverse oxidized 5MedC derivatives are the advantages of this PyAOP-based C4-amination method. In the experiment, the researchers used many compounds, for example, ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6HPLC of Formula: 56602-33-6)
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is used as a reagent for peptide coupling, lactonization, selective esterification, amidation of alfa amino acids without racemization and synthesis of magnolamide for antioxidative activity and catalyst for 9-acridinecaroboxamide derivative. It is also used as a precursor for the synthesis of phenyl esters of amino acids.HPLC of Formula: 56602-33-6
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics