In 2015,Ying, Li; Shuqin, Han; Uryu, Toshiyuki; Yoshida, Takashi published 《Synthesis of new spherical polylysine oligosaccharide dendrimers with C6 methylene spacer》.Sen’i Gakkaishi published the findings.SDS of cas: 56602-33-6 The information in the text is summarized as follows:
New first, second, and third generation sphere-type polylysine glycodendrimers with cellobiose units at the terminal (first, second, and third generation cellobiose-C6 spacer-polylysine dendrimers) were synthesized from 1,4- diaminobutane as a starting compound Repeated condensations by N, N- bis(tert- butoxycarbonyl)-L-lysine (di-boc-lysine) and deprotection of the boc groups gave the first, second, and third generation sphere-type polylysine dendrimers with 4, 8, and 16 amino groups at the terminal in 75%, 82%, and 83% yields,resp. To increase the flexibility of attached oligosaccharides at the terminal, a methylene spacer with six methylene carbons (C6 methylene spacer) was introduced between the polylysine dendrimers and cellobiose; i.e., Et 1-hydroxylhexanoate was reacted with peracetylated α-D-cellobiosyl bromide to afford 2, 2′, 3, 3′, 4′, 6, 6′-hepta-O-acetyl-1-O-(6-ethoxycarbonylpentoxy)-β-D-cellobioside. After hydrolysis of the acetyl and Et ester groups to recover hydroxyl groups and carboxylic acid, the obtained cellobiose unit with a carboxylic acid at the end of the C6 methylene spacer was condensed with the terminal amino groups of the polylysine dendrimers to give first, second, and third generation sphere-type cellobiose-C6 spacer-polylysine dendrimers in 48%, 53%, and 55% yields, resp. The cellobiose unit was connected by the peptide bond to the polylysine dendrimers through the C6 methylene spacer without decomposition of the cellulobiose structure. MALDI TOF MS measurements gave signals that decreased at regular intervals because the mol. weight of the cellobiose unit was around 444 Da and it was found that the average substitution of the cellobiose unit gave nearly 4 among 4, 6.8 among 8, and 11 units among 16 terminal amino groups in the first, second, and third generation polylysine dendrimers, resp., on high resolution 1H NMR and MALDI TOF MS spectra. In the part of experimental materials, we found many familiar compounds, such as ((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6SDS of cas: 56602-33-6)
((1H-Benzo[d][1,2,3]triazol-1-yl)oxy)tris(dimethylamino)phosphonium hexafluorophosphate(V)(cas: 56602-33-6) is a peptide coupling reagent. Can be used in the preparation of phenyl esters of amino acids which have been shown to be valuable as blocked derivatives of amino acids in the field of peptide synthesis.SDS of cas: 56602-33-6
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics