In 2022,Jiang, Zi-Yu; Huang, Zhe-Yao; Yang, Hong; Zhou, Lin; Li, Qing-Han; Zhao, Zhi-Gang published an article in RSC Advances. The title of the article was 《Cs2CO3 catalyzed direct aza-Michael addition of azoles to α,β-unsaturated malonates》.Recommanded Product: 1H-1,2,3-Triazole The author mentioned the following in the article:
A highly efficient method for the synthesis of pyrazole derivatives I (R1 = Pr, Ph, 2-furyl, etc.; R2 = Me, Et, iso-Pr, tert-butyl; R3 = H, Cl, Me, Br; R4 = H, Me, Br) and some other azole derivatives e.g., II via a direct aza-Michael addition of azoles – pyrazole/e.g., 1H-1,2,3-triazole to α,β-unsaturated malonates R1HC=C(C(O)2R2)2 using Cs2CO3 as a catalyst, has been successfully developed. A series of azole derivatives have been obtained in up to 94% yield and the reaction could be amplified to gram scale in excellent yield in the presence of 10 mol% of Cs2CO3.1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 1H-1,2,3-Triazole) was used in this study.
1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 1H-1,2,3-Triazole
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics