Park, Gab-Man; Park, Hyun; Oh, Sangtae; Lee, Seokjoon published an article in 2017, the title of the article was Antimalarial activity of C-10 substituted triazolyl artemisinin.Computed Properties of 5301-96-2 And the article contains the following content:
Synthesis of C-10 substituted triazolyl artemisinins I [R = Ph, 4-MeC6H4, 3-ClC6H4, etc.], II and III [R = 4-Ph, 5-Ph, 5-(4-MeC6H4), 5-(3-ClC6H4), etc.] by the Huisgen cycloaddition reaction between dihydroartemisinins and variously substituted 1,2,3-triazoles was described. The antimalarial activities of 32 novel artemisinin derivatives I , II and III were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin I [R = 3-ClC6H4], II [R = 3-ClC6H4] and III [R = 5-(3-ClC6H4), 4-(3-ClC6H4)] showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2
The Article related to substituted triazolyl artemisinin preparation regioselective diastereoselective antimalarial human, dihydroartemisinin triazole huisgen cycloaddition, antimalarial activity, artemisinin, dihydroartemisinin, substituted triazolyl artemisinin, synthesis and other aspects.Computed Properties of 5301-96-2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics