Stanovnik, Branko published the artcileAn unequivocal synthesis of some substituted 1,2,4-triazolo[1,5-a]pyrimidines, Synthetic Route of 24415-66-5, the main research area is aminopyrimidine condensation formamide acetal; intramol cyclocondensation chlorohydroxyiminomethyleneaminomethylpyrimidine; pyrimidine hydroxyiminomethyleneamino cyclization; triazolopyrimidine chloro methyl.
Condensation of 2-amino-4-chloro-6-methylpyrimidine (I, R = NH2) with Me2NCH(OMe)2 gave imino derivative I (R = N:CHNMe2) (II) in 22% yield. Condensation of II with HONH2.HCl gave 93% I (R = NHCH:NOH), which underwent cyclization with polyphosphoric acid to give triazolopyrimidine III (R1 = Me, R2 = Cl) in 11% yield. Reductive dechlorination gave 90% III (R1 = Me, R2 = H). Cyclocondensation of 3-amino-1,2,4-triazole with EtO2CCH2Ac, chlorination, and reductive dechlorination gave isomeric triazolopyrimidine III (R1 = H, R2 = Me).
Monatshefte fuer Chemie published new progress about Cyclocondensation reaction, regioselective. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Synthetic Route of 24415-66-5.
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics