Ren, Xiao-hui published the artcileSynthesis, crystal structures and antifungal activity of novel triazole compounds containing 1,3-dioxolane, Application In Synthesis of 86386-77-8, the publication is Yaoxue Shijian Zazhi (2012), 30(5), 344-347, database is CAplus.
To synthesize the geometric isomer of (E)-1-((4-(2,4-difluorophenyl)-2-(4-fluorostyryl)-1,3-dioxolan-4-yl)methyl)-1H-l,2,4-triazole, determine their structures by XRD and evaluate their antifungal activities in vitro, the target compounds were prepared from 1H-1,2,4-triazole and 2-chloro-2′,4′-difluoroacetophenone, the key oxirane intermediate was obtained by Corey-Chaykovsky epoxidation The key oxirane intermediate was hydrolyzed in the presence of 9% sulfuric acid, then the product was reacted with 4-fluorinecinnamaldehyde by condensation reaction to afford 6Ka and 6Kb. Their structures were characterized by -1H NMR, MS and XRD. Compound 6Ka belonged to monoclinic crystal system, space group P2(1)/c and had a cis configuration. While compound 6Kb belonged to monoclinic crystal system, space group P2(1)/n and had a trans configuration. Both compounds which showed strong antifungal activities in vitro against five fungi. The antifungal activities of compound 6Kb was better than that of 6Ka. The trans configuration of this kind had a predominant in vitro antifungal activities than the corresponding cis configuration.
Yaoxue Shijian Zazhi published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Application In Synthesis of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics