Solid-phase synthesis and characterization of N-methyl-rich peptides was written by Teixido, M.;Albericio, F.;Giralt, E.. And the article was included in Journal of Peptide Research in 2005.Related Products of 156311-83-0 The following contents are mentioned in the article:
A library of peptides was synthesized on solid phase. As a result of the high N-methylamino acid content in the peptides, their syntheses were challenging. The coupling of protected N-methylamino acids with N-methylamino acids generally occurs in low yield. PyAOP or PyBOP/HOAt, are the most promising coupling reagents for these couplings. When a peptide contains an acetylated N-methylamino acid at the N-terminal position, loss of Ac-N-methylamino acid occurs during TFA cleavage of the peptide from the resin. Other side reactions resulting from acidic cleavage are described here, including fragmentation between consecutive N-methylamino acids and formation of diketopiperazines (DKPs). The time of cleavage is shown to greatly influence synthetic results. Finally, high-performance liquid chromatog. (HPLC) profiles of N-methyl-rich peptides show multiple peaks because of slow conversion between conformers. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Related Products of 156311-83-0).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Related Products of 156311-83-0
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics