Liang, Shuang published the artcileSynthesis and antifungal activity of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-(4-substituted acyl piperazin-1-yl)-2-propanols, Quality Control of 86386-77-8, the publication is Journal of Medical Colleges of PLA (2004), 19(3), 142-145, database is CAplus.
The objective was to study the effect of fluconazole derivatives from a side chain containing 4-substituted acyl piperazine-1-yl on antifungal activity. Fourteen title compounds, e.g., I, were synthesized and confirmed by the elementary anal., 1HNMR and IR spectra. Five deep fungal strains and 3 shallow fungal strains were chosen as the exptl. strains. Min. inhibitory concentrations(MICs) of all title compounds were determined by the method recommended by the National Committee for Clin. Laboratory Standards (NCCLS) using RPMI 1640 test medium. Among the 14 title compounds, 12 were first reported. The results of preliminary antifungal test showed that all the title compounds exhibited potent antifungal activities to a certain extent. The activity of 4 compounds were more than 4 times as high as that of fluconazole and equal to that of ketoconazole against Candida albicans in vitro (MIC80 value ≤ 0.125 μg/mL). Introduction of a side chain containing 4-substituted acyl piperazine-1-yl into the main part of fluconazole has important influence on antifungal activities of title compounds
Journal of Medical Colleges of PLA published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Quality Control of 86386-77-8.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics