Pryde, David C. published the artcileNovel Selective Inhibitors of Neutral Endopeptidase for the Treatment of Female Sexual Arousal Disorder. Synthesis and Activity of Functionalized Glutaramides, Application In Synthesis of 14544-45-7, the publication is Journal of Medicinal Chemistry (2006), 49(14), 4409-4424, database is CAplus and MEDLINE.
Female sexual arousal disorder (FSAD) is a highly prevalent sexual disorder affecting up to 40% of women. Efforts to identify a selective neutral endopeptidase (NEP) inhibitor as a potential treatment for FSAD are reported. The rationale for this approach, together with a description of the medicinal chem. strategy, lead compounds, and SAR investigations are detailed. In particular, the strategy of starting with the clin. precedented selective NEP inhibitor, Candoxatrilat, and targeting low mol. weight and relatively polar mono-carboxylic acids is described. This led ultimately to the prototype development candidate I, for which detailed pharmacol. and pharmacokinetic parameters are presented.
Journal of Medicinal Chemistry published new progress about 14544-45-7. 14544-45-7 belongs to triazoles, auxiliary class Triazoles, name is 5-Nitro-1H-1,2,3-triazole, and the molecular formula is C2H2N4O2, Application In Synthesis of 14544-45-7.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics