Adding a certain compound to certain chemical reactions, such as: 31250-99-4, name is 1-Trityl-1H-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31250-99-4, Product Details of 31250-99-4
EXAMPLE 2 This Example illustrates the preparation of 1-trityl-1,2,4-triazole-5-carboxaldehyde. A solution of 1-trityl-1,2,4-triazole (62.2 g, prepared as described in Example 1) and N,N,N’,N’-tetramethylethylenediamine (23.2 g, 30 ml) in dry tetrahydrofuran (1 l) was cooled to -70 C. under nitrogen. n-Butyllithium (140 ml, 1.6M solution in hexane) was added dropwise, with stirring, at such a rate that the internal temperature was maintained below -60 C. The dark red solution was stirred at -70 C. for at least thirty minutes, treated dropwise with N,N-dimethylformamide (25 ml), allowed to warm to -30 C., then quenched with water (500 ml). The mixture was extracted with ethyl acetate (500 ml), containing a little dichloromethane if any solid precipitated. The extracts were washed with water (6*500 ml), dried over magnesium sulphate, evaporated under reduced pressure and the crude product triturated with ether-hexane (1:1, 150 ml) to give the title compound (60 g, m.p. 134-136 C.). This can be contaminated with 1,2,4-triazole itself, but subsequent stages are not adversly affected and the impurity can be removed at a later stage. NMR (CDCl3): delta7.1-7.4 (15H,m), 8.1(1H,s), 9.15(1H,s).
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Reference:
Patent; Zeneca Limited; US5393732; (1995); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics