1455-77-2, name is 3,5-Diamino-1,2,4-triazole, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Safety of 3,5-Diamino-1,2,4-triazole
Potassium tetranitropropane (200 mg, 0.67 mmol) was added to 20 mL of a mixed solvent of methanol and water (1:1 by volume), then concentrated hydrochloric acid (0.14 mL, 37%, 1.67 mmol) was added dropwise.Then, 3,5-diamino-1,2,4-triazole (293 mg, 1.34 mmol) was added and reacted at room temperature for 2 h. The reaction of the starting material was completely monitored by TLC, and a certain amount of NaHCO3 was added.Then add anhydrous magnesium sulfate to dry, spin dry, and pass the column (PE: EA = 4:1).A yellow solid 168 mg was obtained in 40% yield.
The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chinese Academy Of Sciences Shanghai Organic Chemistry Institute; Yang Jun; Huang Haifeng; Shi Yameng; (17 pag.)CN110128344; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics