New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 6086-21-1, name is 1-Methyl-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1-Methyl-1,2,4-triazole
[00161] To a stirred solution of SM-1 (2.0 g, 24.0 mmol) in THF (20 mL) was added n- butyl lithium (19 mL, 12.0 mmol) at -78 °C dropwise and stirred for 2 h. Then solid CO2 (2 g) was added and stirred at -78 °C for 1 h. The reaction mass was stirred at RT for 16 h. After consumption of the starting material (by TLC), the reaction mixture was quenched with water (3 mL) and the obtained solid was filtered. The solid was triturated with diethylether/n-pentane (10 mL/10 mL). The white color solid was dried under vaccum to afford Int-J (2.0 g, 65.7percent) as white solid. 1H-NMR: (500 MHz, DMSO-i): delta 7.70 (s, 1H), 4.01 (s, 3H) LCMS m/z: 128.3 [M++l]
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Reference:
Patent; NAUREX, INC.; LOWE, John, A.; KHAN, M., Amin; WO2014/120800; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics