Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 65705-44-4, is researched, SMILESS is NC1=NC(C2=CC=C(Br)C=C2)=C(C)S1, Molecular C10H9BrN2SJournal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Sequencing [4+1]-Cycloaddition and Aza-Michael Addition Reactions: A Diastereoselective Cascade for the Rapid Access of Pyrido[2′,1′:2,3]/Thiazolo[2′,3′:2,3]imidazo[1,5-a]quinolone Scaffolds as Potential Antibacterial and Anticancer Motifs, Author is Srinivasulu, Vunnam; Khanfar, Monther; Omar, Hany A.; ElAwady, Raafat; Sieburth, Scott McN; Sebastian, Anusha; Zaher, Dana M.; Al-Marzooq, Farah; Hersi, Fatema; Al-Tel, Taleb H., the main research direction is pyridothiazoloimidazoquinolone preparation antibacterial anticancer.Quality Control of 4-(4-Bromophenyl)-5-methylthiazol-2-amine.
The design and synthesis of a quality compound library containing a small number of skeletally diverse scaffolds, whose members rapidly deliver new chem. probes active against multiple phenotypes, is paramount in drug discovery. In this context, an efficient one-pot strategy for the synthesis of a mini library of sp3 enriched hexahydropyrido[2′,1′:2,3]imidazo[1,5-a]quinolinium and hexahydrothiazolo[2′,3′:2,3] imidazo[1,5-a]quinolinium architectures, is described. This new one-pot method features a combination of Sc(OTf)3-catalyzed [4+1]-cycloaddition with aza-Michael addition reactions.The cascade results in a rapid and diastereoselective formation of these scaffolds via desymmetrization of the oxidative-dearomatization products of phenols. Phenotypic screening of the mini library against multidrug resistant bacteria and a panel of cancer cell lines identified potential antibacterial and anticancer lead drug candidates.Further investigation of the anticancer leads, indicated their activity as tubulin-polymerization inhibitors, representing a promising approach for cancer therapy.
Different reactions of this compound(4-(4-Bromophenyl)-5-methylthiazol-2-amine)Quality Control of 4-(4-Bromophenyl)-5-methylthiazol-2-amine require different conditions, so the reaction conditions are very important.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics