Electric Literature of 41253-21-8, New Advances in Chemical Research in 2021.In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
(2) Prepare a thermometer, a condenser,Add 250 ml of DMF and 1,2,4-triazole sodium salt (18.5 g 203 mmol) to a 250 ml four-neck reaction flask of a stirrer.Add 1-chloro-2-(4-chlorophenyl)-3-cyclopropylbutan-2-ol (44 g, 170 mmol),Heat to 100 C, reaction 60 ~ 100min, sample analysis,When the content of 1-chloro-2-(4-chlorophenyl)-3-cyclopropylbutan-2-ol is less than 1%,It is considered as the end of the reaction. Cool to room temperature,The reaction droplets were added to 120 ml of cold water.The precipitated solid was stirred, filtered, washed with water, dried.A cyproconazole having a content of 96% was obtained in a weight yield of 90%.
The potential utility of systematic synthetic strategy will be applicable to efficient generations of chemical libraries of compounds to find ‘hit’ molecules.Read on for other articles about Sodium 1,2,4-triazol-1-ide, hurry up and to see.
Reference:
Patent; Huai’an Guorui Chemical Co., Ltd.; Zhang Pu; Li Ming; Jin Yucun; Chen Chao; Zhong Yu; Chen Mingguang; Wang Fengyun; (8 pag.)CN109400542; (2019); A;,
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