In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 81606-79-3, name is 2-(1,2,4-Triazol-1-yl)acetonitrile belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 81606-79-3
A mixture of 4-(3-formylphenyl)butanoic acid (960 mg, 5 mmol), 2-(lH-l,2,4- triazol-l-yl)acetonitrile (1.08 g, 10 mmol) and TEA (2.52 g, 25 mmol) in toluene (10 mL) was stirred in microwave reactor at 150 C for 1.5 h. After cooling to rt, the mixture was concentrated to dryness, the residue was purified by column chromatography (ethyl acetate / petroleum ether 0 – 50% as eluent) to afford 4-(3-(2-cyano-2-(lH-l,2,4-triazol-l-yl)vinyl)phenyl)butanoic acid as a light yellow solid (605 mg, 43% yield).
The synthetic route of 81606-79-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; PRINCIPIA BIOPHARMA INC.; LOU, Yan; OWENS, Timothy Duncan; BRAMELD, Kenneth Albert; GOLDSTEIN, David Michael; (171 pag.)WO2019/99576; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics