A new synthetic route of Ethyl 1H-1,2,4-triazole-5-carboxylate

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 64922-04-9

Research speed reading in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 64922-04-9, name is Ethyl 1H-1,2,4-triazole-5-carboxylate belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Computed Properties of C5H7N3O2

EXAMPLE 11 A mixture of ethyl 1,2,4-triazole-3-carboxylate (1.41 g, 0.01 mole) and beta-D-ribofuranosyl-1,2,3,5-tetraacetate (3.18 g, 0.01 mole) was melted and then 0.095 g of p-toluenesulfonic acid was added thereto. The reaction mixture was reacted for 3 hours, while maintaining the temperature of the reaction mixture at 95+-5 C. And then, the reaction mixture was crystallized with 20 ml of methanol to give 3.27 g of 1-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)-1,2,4-triazole-3-carboxylic acid ethyl ester (yield: 82%). NMR (CDCl3) delta (ppm): 1.43(t, 3H), 2.12(t, 9H), 4.00(m, 2H), 4.26(m, 1H), 4.48(m, 2H), 5.57(t, 1H), 5.77(q, 1H), 6.10(d, 1H), 8.50(s, 1H)

The catalyzed pathway has a lower Ea, but the net change in energy that results from the reaction is not affected by the presence of a catalyst. In my other articles, you can also check out more blogs about 64922-04-9

Reference:
Patent; Lee, Tai-Au; Park, Nam-Jin; Khoo, Ja-Heouk; Lee, Byung-Cheol; US2003/120064; (2003); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics