Al-Azmi, Amal published the artcileAlkylation of azoles: synthesis of new heterocyclic-based AT1-non-peptide angiotensin (II) receptor antagonists, COA of Formula: C4HN5, the publication is Journal of Heterocyclic Chemistry (2007), 44(3), 515-520, database is CAplus.
Several analogs of Losartan (I) were synthesized as potential non-peptide angiotensin (II) receptor antagonists. In these non-peptide analogs, e.g., II, the tetrazole and the substituted imidazole rings of Losartan were replaced, resp., by a carboxylic acid function or its Me ester and substituted triazole, imidazole or benzimidazole moieties. The biphenyl bromide precursor (BPE) used to introduce the linker between the acid/ester function and the heterocyclic moiety was synthesized using Suzuki biphenyl coupling and then incorporated into the target mol. by simple nucleophilic substitution. The fixed N-aryl isomeric forms of several azole and benzimidazole tautomers were successfully separated by HPLC using 50% aqueous acetonitrile as eluent. Intermediate reaction products and final target compounds were fully characterized spectroscopically.
Journal of Heterocyclic Chemistry published new progress about 53817-16-6. 53817-16-6 belongs to triazoles, auxiliary class Triazoles, name is 1H-1,2,3-Triazole-4,5-dicarbonitrile, and the molecular formula is C4HN5, COA of Formula: C4HN5.
Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics