Use of onium salt-based coupling reagents in peptide synthesis was written by Albericio, Fernando;Bofill, Josep M.;El-Faham, Ayman;Kates, Steven A.. And the article was included in Journal of Organic Chemistry in 1998.Application of 156311-83-0 The following contents are mentioned in the article:
Peptide coupling methods derived from onium salts based on 1-hydroxybenzotriazole (HOBt) and 1-hydroxy-7-azabenzotriazole (HOAt) are becoming incorporated in synthetic strategies more frequently than the classical carbodiimide methods. The authors have correlated the reactivity of various onium salts derived from HOXt (X = A, B), with the structure of the reagents in question. It was confirmed that the aza derivatives are more reactive than the parent benzotriazole derivatives in both activation and coupling. Also, the activation step is determined by the structure of the carbon skeleton, where pyrrolidino derivatives appear to be reagents of choice relative to the piperidino analogs or those derived from trialkylamines. Although phosphonium salts are slightly less reactive than the corresponding aminium/uronium salts, the former should be used for the activation of hindered species, since the latter may lead to the formation of guanidino derivatives This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Application of 156311-83-0).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Among the nitrogen-containing heterocyclic compounds, triazoles emerge with superior pharmacological applications.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Application of 156311-83-0
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics