Pyrrolidide formation as a side reaction during activation of carboxylic acids by phosphonium salt coupling reagents was written by Alsina, Jordi;Barany, George;Albericio, Fernando;Kates, Steven A.. And the article was included in Letters in Peptide Science in 1999.SDS of cas: 156311-83-0 The following contents are mentioned in the article:
Pyrrolidide derivatives are observed as unwanted byproducts from slow reactions of activated carboxylates with nucleophilic amines, as mediated by phosphonium salt coupling reagents (PyAOP, PyBOP, PyBroP). This side reaction is attributed to the presence of small amounts (e.g., 0.5%, weight/weight) of pyrrolidine as a contaminant to com. phosphonium salts, and does not occur when the reagents are crystallized before their use in coupling reactions. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0SDS of cas: 156311-83-0).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.SDS of cas: 156311-83-0
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics