I found the field of Biochemistry & Molecular Biology; Chemistry; Polymer Science very interesting. Saw the article Screening and analysis of agouti signaling protein interaction partners in Pelodiscus sinensis suggests a role in lipid metabolism published in 2020.0. Category: Triazoles, Reprint Addresses Si, YX (corresponding author), Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou 310053, Peoples R China.; Qian, GY (corresponding author), Zhejiang Wanli Univ, Coll Biol & Environm Sci, Ningbo 315100, Peoples R China.. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine
Agouti signaling protein (ASP) is a secreted paracrine protein that has been widely reported to function in melanogenesis and obesity and could potentially be a core protein that regulates the color and fatty phenotype of P. sinensis. In this study, we screened out interacting proteins of ASP by combined co-immunoprecipitation mass spectrometry (CoIP-MS), yeast two hybrid (Y2H) analysis, and computational predictions. We performed docking of ASP with its well-known receptor melanocortin receptor 4 (MC4R) to predict the binding capacity and to screen out actual ASP interacting proteins, CoIP-MS was performed where identified 32 proteins that could bind with ASP and Y2H confirmed seven proteins binding with ASP directly. CoIP-MS and Y2H screening results including PPI prediction revealed that vitronectin (VIN), apolipoprotein Al (AP0A1), apolipoprotein B (APOB), and filamin B (FLNB) were the key interacting proteins of ASP. VTN, AP0A1, and APOB are functional proteins in lipid metabolism and various skin disorders, suggesting ASP may function in lipid metabolism through these partners. This study provided protein-protein interaction information of ASP, and the results will promote further research into the diverse roles of ASP, as well as its binding partners, and their function in different strains of P. sinensis. (C) 2019 Published by Elsevier B.V.
Category: Triazoles. Welcome to talk about 61-82-5, If you have any questions, you can contact Zhang, LL; Yin, SJ; Zheng, XY; Chen, XW; Wang, Q; Park, YD; Qian, GY; Si, YX or send Email.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
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