Analyzing the synthesis route of 1001401-62-2

The chemical industry reduces the impact on the environment during synthesis 2-(2H-1,2,3-Triazol-2-yl)benzoic acid. I believe this compound will play a more active role in future production and life.

Synthetic Route of 1001401-62-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, This compound has unique chemical properties. The synthetic route is as follows.

2-(2H-1,2,3-Triazol-2-yl)benzoic acid (0.02 g, 0.1 mmol), HOBt.H2O (0.022 g, 0.14 mmol), and EDC.HCl (0.027 g, 0.14 mmol) were added to a solution of N-ethyl-2-[1-(5-fluoropyridin-2-yl)-1H-pyrazol-3-yl]ethanamine (0.022 g, 0.09 mmol) prepared in Reference Example 10 in DMF (0.8 mL), followed by stirring at room temperature for 2 hours. An aqueous NaHCO3 solution was added to the reaction mixture, followed by extract with EtOAc. The solvent was distilled off under reduced pressure. The resulting residue was purified by column chromatography (HP-Sil: 10 g, hexane/EtOAc=80/20 to 0/100, KP-NH: 11 g, hexane/EtOAc=88/12 to 0/100), followed by washing with Et2O with stirring to give the titled compound (0.013 g, colorless solid). LCMS retention time: 5.54 min (Condition 1) MS (ESI pos.) m/z: 406 [M+H]+

The chemical industry reduces the impact on the environment during synthesis 2-(2H-1,2,3-Triazol-2-yl)benzoic acid. I believe this compound will play a more active role in future production and life.

Reference:
Patent; TAISHO PHARMACEUTICAL CO., LTD.; Suzuki, Ryo; Futamura, Aya; Abe, Masahito; Kashiwa, Shuhei; Hattori, Nobutaka; Nozawa, Dai; Ohta, Hiroshi; Araki, Yuko; US2014/81025; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics