Synthetic Route of 16681-70-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16681-70-2 as follows.
[0622] (2S,4S)-4-Amino-5-biphenyl-4-yl-2-cyanomethylpentanoicacid ethyl ester (70 mg, 199 f.tmol) was combinedwith DMF (1 mL), HATU (76 mg, 199 flillOI), DIPEA (104f.LL, 596 f.tmol), and 3H-[1,2,3]triazole-4-carboxylic acid (22mg, 199 flillOI) and the mixture was stirred at room temperaturefor 20 minutes. The solvent was evaporated and the crudemixture was purified by normal phase chromatography(0-100% EtOAc/hexanes) to yield Compound 1 (60 mg).
According to the analysis of related databases, 16681-70-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics