Adding some certain compound to certain chemical reactions, such as: 23579-79-5, name is 3,5-Dibromo-1-methyl-1H-1,2,4-triazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 23579-79-5. 23579-79-5
A mixture of 1,2,3,4-tetrahydroisoquinoline (1.1 g, 8.3 mmol), intermediate 32 (0.2 g, 8.3 mmol), K2CO3 (2.3 g, 16.6 mmol) in DMF (20 ml) was heated at 160 C. for 45 min using microwave irradiation. The r.m. was cooled and then poured onto H2O and extracted with DCM. The organic layer was dried (MgSO4) and concentrated under reduced pressure. The residue was purified by flash column chromatography over silica gel (eluent: DCM/MeOH from 100/0 to 97/3). The product fractions were collected and concentrated in vacuo, yielding 900 mg of intermediate 33 (40%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 3,5-Dibromo-1-methyl-1H-1,2,4-triazole.
Reference:
Patent; Van Brandt, Sven Franciscus Anna; De Cleyn, Michel Anna Jozef; Gijsen, Henricus Jacobus Maria; Berthelot, Didier Jean-Claude; Surkyn, Michel; US2012/295891; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics