Adding a certain compound to certain chemical reactions, such as: 288-36-8, name is 1H-1,2,3-Triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 288-36-8, HPLC of Formula: C2H3N3
To a mixture of the product from step 2 (7.9 g, 38 mmol), Cs2C03 (24.8 g,76 mmol) and Cul (2.88 g, 7.6 mmol) in DMF (200 mL) were added 2H-[l,2,3]triazole (5.24 g,76 mmol) and N,N’-dimethyl-cyclohexane- 1,2-diamine (0.9 g, 6.5 mmol) and the mixture was stirred at 110 C overnight. The cooled mixture was adjusted to pH ~12 with 1M sodium hydroxide and extracted withEtOAc (50 mL x 3). The aqueous layer was adjusted to pH ~4 with 1M HC1 and extracted with EtOAc (50 mLx4). The extracts were dried over Na2S04, filtered, the filtrate concentrated in vacuo and the residue purified by chromatography on silica (Petroleum ether:EtOAc =10:1) to provide the title compound. LRMS m/z (M+H) 196.0 found, 196.0 required.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; MERCK SHARP & DOHME CORP.; LIVERTON, Nigel; KUDUK, Scott D.; BESHORE, Douglas; LUO, Yunfu; MENG, Na; YU, Tingting; (114 pag.)WO2016/65585; (2016); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics