Analyzing the synthesis route of 3222-47-7

Different reactions of this compound(6-Methylnicotinic acid)Reference of 6-Methylnicotinic acid require different conditions, so the reaction conditions are very important.

Reference of 6-Methylnicotinic acid. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 6-Methylnicotinic acid, is researched, Molecular C7H7NO2, CAS is 3222-47-7, about Catalytic deoxygenative coupling of aromatic esters with organo-phosphorus compounds. Author is Kurosawa, Miki B.; Isshiki, Ryota; Muto, Kei; Yamaguchi, Junichiro.

We have developed a deoxygenative coupling of aromatic esters with diarylphosphine oxides/dialkyl phosphonates under palladium catalysis. Reaction of Ph aromatic esters ArCO2Ph with hydrophosphoryl compounds HP(O)R2 (R = Ph, aryl, BuO) in the presence of PdCl2/dcype and HCO2Na reductant afforded benzyl phosphine oxides, phosphonates and phosphinates ArCH2P(O)R2. In this reaction, aromatic esters can work as novel benzylation reagents to give the corresponding benzylic phosphorus compounds The key of this reaction is the use of Ph esters, an electron-rich diphosphine as a ligand, and sodium formate as a hydrogen source. Arylcarboxylic acids were also applicable in this reaction using (Boc)2O as an additive. Palladium/dcype worked as a bifunctional catalyst to activate the acyl C-O bond of the ester and to support the reduction with sodium formate.

Different reactions of this compound(6-Methylnicotinic acid)Reference of 6-Methylnicotinic acid require different conditions, so the reaction conditions are very important.

Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics