6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 4-(1,2,4-Triazol-1-yl)aniline
A mixture of the formamidine from step 1 (76 mg) and 4-triazolylaniline(24 mg) in AcOH (2 ml) was heated to 125 for 1 h. After cooling, the mixture was diluted and basified with IN NaOH (20 ml). The resulting ppt was isolated by filtration, washed with DCM then triturated with MeOH / acetone. The filtrate was concentrated to give the title compound (22 mg) as a light green solid. 1H NMR delta 10.45 (IH, br s), 9.3 (IH, s), 8.88 (IH, s), 8.6 (IH, s), 8.26 (IH, s),8.14 (3H, m), 7.87 (5H5 m), 7.12 (2H5 d, J 8.85Hz), 3.78 (4H, m), 3.21 (4H5 m) ; LC- MS rt 2.28 m/z 450 ES+.
The synthetic route of 6523-49-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics