In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6818-99-1, name is 3-Chloro-1,2,4-triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. category: Triazoles
300 mg of intermediate 31, sodium hydride(60%, oil) 45 mg and DMF 1.3 mL, 116 mg of 3-chloro-1 H-1,2,4-triazole was added under ice cooling. After the reaction mixture was stirred for 20 hours under ice cooling, water was added to the reaction mixture,And extracted with ethyl acetate. The obtained organic layer was washed with water,After drying with anhydrous sodium sulfate, it was dried under reduced pressure.The obtained residue was subjected to silica gel chromatography,240 mg of the present compound 1299 described below was obtained.
The synthetic route of 6818-99-1 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Sumitomo Chemical; Ikari, Kaori; (123 pag.)JP2019/6686; (2019); A;,
1,2,3-Triazole – Wikipedia,
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