1533519-84-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 1533519-84-4, name is 4-(4-Cyclopropylnaphthalen-1-yl)-1H-1,2,4-triazole-5(4H)-thione belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.
In a 100 ml three-necked flask equipped with a stirrer and a thermometer, 25 ml of DMF was added, the intermediate (III)2.67 g, stirred at room temperature, 1.45 g of potassium carbonate was added, and 1.61 g of methyl bromoacetate was added dropwise at 25 C,Stirring was continued for 3 hours; 50 ml of water was added and extracted with ethyl acetate 50 ml x3 to combine the organic phase,The ethyl acetate was concentrated and concentrated, and 50 ml of methanol was added thereto. The crystals were recrystallized, filtered and dried to give 3.22 g of product,Namely intermediate (IV), yield 99.5%.
The synthetic route of 1533519-84-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Chengdu Baoyu Pharmaceutical Co., Ltd.; Lei, Lang; Li, Shanwei; Xiong, Bo; (10 pag.)CN105906576; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics