Application of 16681-70-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-70-2, name is 1H-[1,2,3]Triazole-4-carboxylic acid, This compound has unique chemical properties. The synthetic route is as follows.
In a 25 mL round bottom flask, compound 18 (70 mg, 0.12 mmol) was dissolved in MeOH (3 mL)The reaction was terminated by TLC, and the solvent was removed under reduced pressure to give a white residue.The residue was dissolved in DMF (2 mL).Adding to a reaction solution of compound 23 (16 mg, 0.14 mmol), DIPEA (61 mg, 0.47 mmol) and HATU (58 mg, 0.15 mmol) in DMF (3 mL)Stir at room temperature for 4 hours,The solvent was removed under reduced pressure.The residue was added to trifluoroacetic acid (3 mL) and stirred at room temperature for 2 hours.The solvent was removed under reduced pressure.The residue was prepared in reverse by C18 high performance liquid chromatography.The mobile phase was acetonitrile (0.1% trifluoroacetic acid) and water (0.1% trifluoroacetic acid) to give compound 25 (12 mg, a three-step reaction yield 29%).White solid.
The chemical industry reduces the impact on the environment during synthesis 1H-[1,2,3]Triazole-4-carboxylic acid. I believe this compound will play a more active role in future production and life.
Reference:
Patent; Beijing University The First Hospital; Yang Xing; Yang Zhi; Xi Zhen; Liu Futao; Duan Xiaojiang; (24 pag.)CN109748896; (2019); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics